Fungal infection due to Scedosporium apiospermum

A fungal infection due to *Scedosporium apiospermum* is an opportunistic mycosis caused by a ubiquitous, saprophytic, filamentous environmental mold It primarily manifests as localized soft-tissue trauma or pulmonary disease in immunocompetent individuals, but frequently causes aggressive, invasive, or disseminated disease in severely immunocompromised populations, such as solid organ or hematopoietic cell transplant recipients and patients receiving prolonged corticosteroid therapy Pathophysiol...

It primarily manifests as localized soft-tissue trauma or pulmonary disease in immunocompetent individuals, but frequently causes aggressive, invasive, or disseminated disease in severely immunocompromised populations, such as solid organ or hematopoietic cell transplant recipients and patients receiving prolonged corticosteroid therapy

Pathophysiologically, it is characterized by tissue angioinvasion, necrosis, and hematogenous dissemination to secondary sites—most notably the central nervous system, eyes, and skin—and is clinically challenging to treat due to intrinsic resistance to conventional antifungal agents such as amphotericin B