Giant cell arteritis

Giant cell arteritis is a chronic, systemic granulomatous vasculitis that primarily targets medium- and large-sized arteries, notably the aorta and the extracranial branches of the carotid arteries Pathophysiologically, transmural vascular inflammation, fragmentation of the internal elastic lamina, and intimal hyperplasia cause luminal narrowing, frequently manifesting as temporal headaches, jaw claudication, scalp tenderness, systemic inflammation, and ischemic complications such as irreversibl...

Giant cell arteritis is a chronic, systemic granulomatous vasculitis that primarily targets medium- and large-sized arteries, notably the aorta and the extracranial branches of the carotid arteries The condition occurs almost exclusively in adults aged 50 and older, with peak incidence between 70 and 80 years of age and a higher prevalence in women Pathophysiologically, transmural vascular inflammation, fragmentation of the internal elastic lamina, and intimal hyperplasia cause luminal narrowing...

Pathophysiologically, transmural vascular inflammation, fragmentation of the internal elastic lamina, and intimal hyperplasia cause luminal narrowing, frequently manifesting as temporal headaches, jaw claudication, scalp tenderness, systemic inflammation, and ischemic complications such as irreversible vision loss