Granulomatosis infantiseptica

Granulomatosis infantiseptica is a severe, life-threatening form of early-onset neonatal listeriosis resulting from transplacental transmission of *Listeria monocytogenes* during maternal bacteremia The condition primarily affects fetuses and neonates, manifesting in utero or within the first hours to days of life with fulminant septicemia and multisystem involvement Pathophysiologically, it is characterized by hematogenous dissemination leading to widespread pyogranulomatous lesions and microab...

Granulomatosis infantiseptica is a severe, life-threatening form of early-onset neonatal listeriosis resulting from transplacental transmission of *Listeria monocytogenes* during maternal bacteremia The condition primarily affects fetuses and neonates, manifesting in utero or within the first hours to days of life with fulminant septicemia and multisystem involvement

Pathophysiologically, it is characterized by hematogenous dissemination leading to widespread pyogranulomatous lesions and microabscesses throughout internal organs—predominantly the liver, spleen, lungs, adrenal glands, and central nervous system—often accompanied by characteristic papular or petechial cutaneous eruptions

Pathophysiologically, it is characterized by hematogenous dissemination leading to widespread pyogranulomatous lesions and microabscesses throughout internal organs—predominantly the liver, spleen, lungs, adrenal glands, and central nervous system—often accompanied by characteristic papular or petechial cutaneous eruptions