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Indication

Heart failure with reduced ejection fraction

Heart failure with reduced ejection fraction is a chronic cardiovascular syndrome characterized by the heart's inability to pump sufficient oxygenated blood to meet systemic metabolic demands. Read more about Heart failure with reduced ejection fraction

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About Heart failure with reduced ejection fraction.

Heart failure with reduced ejection fraction is a chronic cardiovascular syndrome characterized by the heart's inability to pump sufficient oxygenated blood to meet systemic metabolic demands.

Affecting the cardiovascular system in pediatric and adult populations, it is clinically defined by signs and symptoms of heart failure alongside left ventricular systolic dysfunction, specifically a left ventricular ejection fraction of 40% or less.

Pathophysiologically, it involves progressive left ventricular dilatation, adverse myocardial remodeling, and neurohormonal activation that lead to impaired contractile function, elevated intracardiac filling pressures, pulmonary and systemic venous congestion, and reduced cardiac output.

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