Heartburn

Heartburn, or pyrosis, is a common upper gastrointestinal symptom characterized by a painful, burning sensation located retrosternally behind the breastbone that frequently radiates upward toward the neck and throat While occasional episodes represent uncomplicated physiological gastroesophageal reflux, frequent or persistent heartburn serves as the hallmark clinical feature of gastroesophageal reflux disease

Heartburn, or pyrosis, is a common upper gastrointestinal symptom characterized by a painful, burning sensation located retrosternally behind the breastbone that frequently radiates upward toward the neck and throat Pathophysiologically, it occurs when transient relaxation, hypotonicity, or mechanical disruption of the lower esophageal sphincter permits the retrograde flow of acidic gastric contents into the esophagus, leading to chemical irritation of mucosal chemoreceptors and sensory nerve en...

It primarily affects the esophageal mucosa across diverse patient populations and is most often triggered postprandially or when recumbent Pathophysiologically, it occurs when transient relaxation, hypotonicity, or mechanical disruption of the lower esophageal sphincter permits the retrograde flow of acidic gastric contents into the esophagus, leading to chemical irritation of mucosal chemoreceptors and sensory nerve endings While occasional episodes represent uncomplicated physiological gastroe...

It primarily affects the esophageal mucosa across diverse patient populations and is most often triggered postprandially or when recumbent

Pathophysiologically, it occurs when transient relaxation, hypotonicity, or mechanical disruption of the lower esophageal sphincter permits the retrograde flow of acidic gastric contents into the esophagus, leading to chemical irritation of mucosal chemoreceptors and sensory nerve endings

While occasional episodes represent uncomplicated physiological gastroesophageal reflux, frequent or persistent heartburn serves as the hallmark clinical feature of gastroesophageal reflux disease