Hemorrhagic disease of newborn due to vitamin K deficiency

Hemorrhagic disease of the newborn due to vitamin K deficiency, also termed vitamin K deficiency bleeding in neonates and young infants, is an acquired coagulopathy characterized by an inability to form stable blood clots Pathophysiologically, the deficiency impairs hepatic gamma-carboxylation of the vitamin K–dependent clotting factors (II, VII, IX, and X), resulting in inactive procoagulants, prolonged clotting times, and spontaneous hemorrhages that manifest clinically as cutaneous purpura, u...

Hemorrhagic disease of the newborn due to vitamin K deficiency, also termed vitamin K deficiency bleeding in neonates and young infants, is an acquired coagulopathy characterized by an inability to form stable blood clots It primarily affects the hematologic system in neonates and early infants due to naturally low neonatal hepatic stores of vitamin K, minimal transplacental transfer, a sterile gut microflora, and low vitamin K concentrations in unsupplemented breast milk Pathophysiologically, t...

It primarily affects the hematologic system in neonates and early infants due to naturally low neonatal hepatic stores of vitamin K, minimal transplacental transfer, a sterile gut microflora, and low vitamin K concentrations in unsupplemented breast milk

It primarily affects the hematologic system in neonates and early infants due to naturally low neonatal hepatic stores of vitamin K, minimal transplacental transfer, a sterile gut microflora, and low vitamin K concentrations in unsupplemented breast milk