Herpes simplex encephalitis

Herpes simplex encephalitis is an acute or subacute, life-threatening viral infection of the central nervous system characterized by severe, necrotizing inflammation of the brain parenchyma It predominantly affects adults and older children via herpes simplex virus type 1 (HSV-1), while herpes simplex virus type 2 (HSV-2) more frequently causes diffuse disease in neonates or immunocompromised hosts Patients classically present with acute onset of fever, headache, altered mental status, behaviora...

Herpes simplex encephalitis is an acute or subacute, life-threatening viral infection of the central nervous system characterized by severe, necrotizing inflammation of the brain parenchyma Pathophysiologically, the virus typically exhibits a pronounced tropism for the temporal and frontal lobes, causing asymmetric hemorrhagic necrosis, localized cerebral edema, and marked parenchymal destruction Patients classically present with acute onset of fever, headache, altered mental status, behavioral ...

Pathophysiologically, the virus typically exhibits a pronounced tropism for the temporal and frontal lobes, causing asymmetric hemorrhagic necrosis, localized cerebral edema, and marked parenchymal destruction

Pathophysiologically, the virus typically exhibits a pronounced tropism for the temporal and frontal lobes, causing asymmetric hemorrhagic necrosis, localized cerebral edema, and marked parenchymal destruction

Patients classically present with acute onset of fever, headache, altered mental status, behavioral and cognitive changes, seizures, and focal neurological deficits