High density lipoprotein deficiency

High density lipoprotein deficiency (hypoalphalipoproteinemia) is a lipid metabolism disorder characterized by abnormally low circulating levels of high-density lipoprotein cholesterol (HDL-C) Primarily affecting the cardiovascular system, this metabolic state impairs reverse cholesterol transport, significantly increasing the risk of accelerated atherosclerosis and premature coronary artery disease It may occur as an acquired condition secondary to insulin resistance, obesity, smoking, or medic...

High density lipoprotein deficiency (hypoalphalipoproteinemia) is a lipid metabolism disorder characterized by abnormally low circulating levels of high-density lipoprotein cholesterol (HDL-C) Primarily affecting the cardiovascular system, this metabolic state impairs reverse cholesterol transport, significantly increasing the risk of accelerated atherosclerosis and premature coronary artery disease It may occur as an acquired condition secondary to insulin resistance, obesity, smoking, or medic...

It may occur as an acquired condition secondary to insulin resistance, obesity, smoking, or medications, or arise as a primary genetic disorder caused by mutations in genes such as *ABCA1*, *APOA1*, or *LCAT* (as seen in familial HDL deficiency, Tangier disease, and lecithin-cholesterol acyltransferase deficiency)