Indication

Hormone receptor (HR)-positive, HER2-negative advanced female breast cancer

Hormone receptor (HR)-positive, HER2-negative advanced female breast cancer is an invasive malignancy originating in the female mammary epithelium that has progressed to locally advanced, unresectable disease or distant metastases (Stage III–IV). Read more about Hormone receptor (HR)-positive, HER2-negative advanced female breast cancer

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Drugs that treat it

Common Hormone receptor (HR)-positive, HER2-negative advanced female breast cancer therapies.

Showing 1–9 of 24 drugs

FASLODEX (fulvestrant)

ANTIESTROGEN·HORMONE RECEPTOR POSITIVE POSTMENOPAUSAL ADVANCED BREAST CANCER·+1
AstraZeneca Pharmaceuticals

FULVESTRANT

ANTIESTROGEN·HORMONE RECEPTOR POSITIVE POSTMENOPAUSAL ADVANCED BREAST CANCER·+1
SANDOZ

FULVESTRANT

ANTIESTROGEN·HORMONE RECEPTOR POSITIVE POSTMENOPAUSAL ADVANCED BREAST CANCER·+1
GLENMARK PHARMA

FULVESTRANT

ANTIESTROGEN·HORMONE RECEPTOR POSITIVE POSTMENOPAUSAL ADVANCED BREAST CANCER·+1
SAGENT PHARMACE

FULVESTRANT

HORMONE RECEPTOR POSITIVE POSTMENOPAUSAL ADVANCED BREAST CANCER·+1
MYLAN INSTITUTI

FULVESTRANT

HORMONE RECEPTOR POSITIVE POSTMENOPAUSAL ADVANCED BREAST CANCER·+1
ASTRAZENECA LP/

FULVESTRANT

ANTIESTROGEN·HORMONE RECEPTOR POSITIVE POSTMENOPAUSAL ADVANCED BREAST CANCER·+1
AMNEAL BIOSCIEN

FULVESTRANT

ANTIESTROGEN·HORMONE RECEPTOR POSITIVE POSTMENOPAUSAL ADVANCED BREAST CANCER·+1
FRESENIUS KABI

FULVESTRANT

HORMONE RECEPTOR POSITIVE POSTMENOPAUSAL ADVANCED BREAST CANCER·+1
Actavis Pharma
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About Hormone receptor (HR)-positive, HER2-negative advanced female breast cancer.

Hormone receptor (HR)-positive, HER2-negative advanced female breast cancer is an invasive malignancy originating in the female mammary epithelium that has progressed to locally advanced, unresectable disease or distant metastases (Stage III–IV).

Pathophysiologically, the tumor cells express estrogen receptors, progesterone receptors, or both, which drive oncogenic cell proliferation and survival in response to endocrine signaling.

Concurrently, these malignant cells do not overexpress human epidermal growth factor receptor 2 (HER2) protein or exhibit *ERBB2* gene amplification.

Although this subtype accounts for the majority of female breast cancer diagnoses and maintains a reliance on hormone-mediated pathways, advanced disease represents an aggressive, largely incurable systemic stage characterized by eventual therapeutic resistance and metastatic spread to sites such as bone, viscera, or distant lymph nodes.

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