Hyperglycemia

Hyperglycemia is a metabolic state characterized by elevated circulating blood glucose levels above the physiologic range, most commonly defined as a fasting plasma glucose of 126 mg/dL or higher or postprandial/random levels exceeding 180 to 200 mg/dL

Hyperglycemia is a metabolic state characterized by elevated circulating blood glucose levels above the physiologic range, most commonly defined as a fasting plasma glucose of 126 mg/dL or higher or postprandial/random levels exceeding 180 to 200 mg/dL While classically associated with diabetes mellitus across pediatric and adult populations, it also arises secondary to acute physiologic stress, critical illness, endocrine disorders, and certain medications like corticosteroids

Hyperglycemia is a metabolic state characterized by elevated circulating blood glucose levels above the physiologic range, most commonly defined as a fasting plasma glucose of 126 mg/dL or higher or postprandial/random levels exceeding 180 to 200 mg/dL While classically associated with diabetes mellitus across pediatric and adult populations, it also arises secondary to acute physiologic stress, critical illness, endocrine disorders, and certain medications like corticosteroids Clinically, acute...

Driven by an absolute or relative deficiency in insulin secretion, peripheral insulin resistance, or excessive hepatic glucose production, it primarily reflects endocrine and metabolic dysfunction While classically associated with diabetes mellitus across pediatric and adult populations, it also arises secondary to acute physiologic stress, critical illness, endocrine disorders, and certain medications like corticosteroids

Driven by an absolute or relative deficiency in insulin secretion, peripheral insulin resistance, or excessive hepatic glucose production, it primarily reflects endocrine and metabolic dysfunction

Clinically, acute elevations may manifest with osmotic symptoms such as polyuria, polydipsia, fatigue, and blurred vision, whereas prolonged or extreme dysregulation poses a risk for life-threatening acute crises and systemic microvascular and macrovascular complications