Kaposi's sarcoma

Kaposi's sarcoma is a low-grade vascular neoplastic disorder caused by infection with human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus Pathophysiologically, the tumor arises from lymphatic endothelial-lineage cells, leading to multifocal vascular proliferation, spindle-cell infiltration, and extravasated erythrocytes Clinically, it manifests as nonpruritic, violaceous, brownish, or reddish macules, plaques, and nodules that commonly involve the skin, oral mucosa, ...

It primarily affects individuals with compromised immune systems—notably people living with advanced HIV infection (AIDS-defining illness) and solid-organ transplant recipients—as well as distinct demographic groups presenting with classic (older Mediterranean or Eastern European men) or endemic (equatorial African) forms

It primarily affects individuals with compromised immune systems—notably people living with advanced HIV infection (AIDS-defining illness) and solid-organ transplant recipients—as well as distinct demographic groups presenting with classic (older Mediterranean or Eastern European men) or endemic (equatorial African) forms

It primarily affects individuals with compromised immune systems—notably people living with advanced HIV infection (AIDS-defining illness) and solid-organ transplant recipients—as well as distinct demographic groups presenting with classic (older Mediterranean or Eastern European men) or endemic (equatorial African) forms Pathophysiologically, the tumor arises from lymphatic endothelial-lineage cells, leading to multifocal vascular proliferation, spindle-cell infiltration, and extravasated eryth...

Clinically, it manifests as nonpruritic, violaceous, brownish, or reddish macules, plaques, and nodules that commonly involve the skin, oral mucosa, and lymph nodes, with potential dissemination to the gastrointestinal and respiratory tracts causing mucosal bleeding or airway compromise