Keratoderma

Keratoderma refers to a heterogeneous group of dermatologic conditions characterized by marked, abnormal thickening and hyperkeratosis of the stratum corneum, most predominantly involving the epidermis of the palms and soles It affects pediatric and adult populations and presents in diffuse, focal, or punctate morphological patterns that may be strictly confined to volar surfaces or exhibit transgradient extension Defining clinical features include yellowish, thickened hyperkeratotic plaques oft...

Keratoderma refers to a heterogeneous group of dermatologic conditions characterized by marked, abnormal thickening and hyperkeratosis of the stratum corneum, most predominantly involving the epidermis of the palms and soles Pathophysiologically, keratodermas can be hereditary—arising from mutations disrupting epidermal differentiation, mechanical integrity, intercellular adhesion, or gap junctions—or acquired secondary to inflammatory dermatoses, malignancies, systemic diseases, or adverse drug...

Keratoderma refers to a heterogeneous group of dermatologic conditions characterized by marked, abnormal thickening and hyperkeratosis of the stratum corneum, most predominantly involving the epidermis of the palms and soles

It affects pediatric and adult populations and presents in diffuse, focal, or punctate morphological patterns that may be strictly confined to volar surfaces or exhibit transgradient extension Pathophysiologically, keratodermas can be hereditary—arising from mutations disrupting epidermal differentiation, mechanical integrity, intercellular adhesion, or gap junctions—or acquired secondary to inflammatory dermatoses, malignancies, systemic diseases, or adverse drug reactions Defining clinical fea...

It affects pediatric and adult populations and presents in diffuse, focal, or punctate morphological patterns that may be strictly confined to volar surfaces or exhibit transgradient extension Defining clinical features include yellowish, thickened hyperkeratotic plaques often complicated by painful fissuring, desquamation, contractures, and secondary bacterial or fungal infections

Pathophysiologically, keratodermas can be hereditary—arising from mutations disrupting epidermal differentiation, mechanical integrity, intercellular adhesion, or gap junctions—or acquired secondary to inflammatory dermatoses, malignancies, systemic diseases, or adverse drug reactions