Kidney disease with reduction in glomerular filtration rate (GFR)

Kidney disease with reduction in glomerular filtration rate (GFR) refers to a clinical state of compromised renal function within the urinary system, characterized by an impaired capacity of the glomeruli to filter metabolic waste and excess fluid from the blood

Kidney disease with reduction in glomerular filtration rate (GFR) refers to a clinical state of compromised renal function within the urinary system, characterized by an impaired capacity of the glomeruli to filter metabolic waste and excess fluid from the blood Pathophysiologically, the progressive loss of functional nephrons leads to decreased renal clearance, resulting in uremic solute accumulation, disrupted fluid and electrolyte homeostasis, and systemic complications such as anemia, minera...

Commonly manifesting as chronic kidney disease—typically defined by an estimated GFR falling below 60 mL/min/1.73 m² or persisting structural and functional decline for at least three months—it affects diverse patient populations, frequently arising secondary to diabetes, hypertension, or primary glomerulopathies