Louse-borne typhus

Louse-borne typhus, also designated epidemic typhus, is an acute, severe systemic rickettsial infection caused by the obligate intracellular bacterium *Rickettsia prowazekii* Clinically, the disease presents with the abrupt onset of high fevers, severe headache, prominent myalgias, and chills, followed typically by a centrifugal maculopapular rash, with severe cases progressing to confusion, delirium, renal failure, or life-threatening multiorgan dysfunction

Louse-borne typhus, also designated epidemic typhus, is an acute, severe systemic rickettsial infection caused by the obligate intracellular bacterium *Rickettsia prowazekii* It primarily affects populations living in overcrowded, unhygienic environments—such as refugee camps, prisons, and regions experiencing war, famine, or extreme poverty—where transmission is facilitated by the human body louse (*Pediculus humanus corporis*) Pathophysiologically, the bacteria target and multiply within vascu...

It primarily affects populations living in overcrowded, unhygienic environments—such as refugee camps, prisons, and regions experiencing war, famine, or extreme poverty—where transmission is facilitated by the human body louse (*Pediculus humanus corporis*)

It primarily affects populations living in overcrowded, unhygienic environments—such as refugee camps, prisons, and regions experiencing war, famine, or extreme poverty—where transmission is facilitated by the human body louse (*Pediculus humanus corporis*)

Clinically, the disease presents with the abrupt onset of high fevers, severe headache, prominent myalgias, and chills, followed typically by a centrifugal maculopapular rash, with severe cases progressing to confusion, delirium, renal failure, or life-threatening multiorgan dysfunction

Clinically, the disease presents with the abrupt onset of high fevers, severe headache, prominent myalgias, and chills, followed typically by a centrifugal maculopapular rash, with severe cases progressing to confusion, delirium, renal failure, or life-threatening multiorgan dysfunction