Metastatic castration-resistant prostate cancer

Metastatic castration-resistant prostate cancer is an advanced, incurable malignancy of the male reproductive system that has disseminated beyond the prostate gland to distant anatomical sites, most commonly the bones, distant lymph nodes, or visceral organs

Metastatic castration-resistant prostate cancer is an advanced, incurable malignancy of the male reproductive system that has disseminated beyond the prostate gland to distant anatomical sites, most commonly the bones, distant lymph nodes, or visceral organs It is defined clinically and biochemically by progressive disease—evidenced by rising serum prostate-specific antigen levels, objective radiologic progression, or worsening clinical symptoms—despite therapeutic or surgical androgen deprivati...

Metastatic castration-resistant prostate cancer is an advanced, incurable malignancy of the male reproductive system that has disseminated beyond the prostate gland to distant anatomical sites, most commonly the bones, distant lymph nodes, or visceral organs

It is defined clinically and biochemically by progressive disease—evidenced by rising serum prostate-specific antigen levels, objective radiologic progression, or worsening clinical symptoms—despite therapeutic or surgical androgen deprivation that maintains serum testosterone at castrate levels

It is defined clinically and biochemically by progressive disease—evidenced by rising serum prostate-specific antigen levels, objective radiologic progression, or worsening clinical symptoms—despite therapeutic or surgical androgen deprivation that maintains serum testosterone at castrate levels

Pathophysiologically, the tumor develops resistance to standard testosterone-suppressing therapies through adaptive mechanisms such as androgen receptor gene alterations, splice variants, and intracrine steroid synthesis, allowing persistent oncogenic signaling