Minimal change glomerulonephritis

Minimal change glomerulonephritis, also known as minimal change disease or minimal change nephropathy, is a primary glomerular disorder and the leading cause of idiopathic nephrotic syndrome in children, though it also occurs in adults

Minimal change glomerulonephritis, also known as minimal change disease or minimal change nephropathy, is a primary glomerular disorder and the leading cause of idiopathic nephrotic syndrome in children, though it also occurs in adults

The condition is characterized clinically by the abrupt onset of profound, selective proteinuria leading to marked hypoalbuminemia, generalized edema, and hyperlipidemia

The condition is characterized clinically by the abrupt onset of profound, selective proteinuria leading to marked hypoalbuminemia, generalized edema, and hyperlipidemia

Pathophysiologically, the glomeruli appear structurally normal or show only subtle mesangial alterations on standard light microscopy, but electron microscopy reveals extensive, diffuse effacement of visceral epithelial cell foot processes (podocytes) with preserved renal function and an absence of inflammatory immune complex deposits

Pathophysiologically, the glomeruli appear structurally normal or show only subtle mesangial alterations on standard light microscopy, but electron microscopy reveals extensive, diffuse effacement of visceral epithelial cell foot processes (podocytes) with preserved renal function and an absence of inflammatory immune complex deposits