Multifocal motor neuropathy

Multifocal motor neuropathy is a rare, acquired, immune-mediated disorder of the peripheral nervous system that selectively targets motor nerve fibers while sparing sensory nerves Primarily affecting young to middle-aged adults—predominantly men—it presents with slowly progressive, asymmetrical muscle weakness, fasciculations, and cramping that most frequently begin in the distal upper extremities Pathophysiologically, the condition involves immune-mediated disruption of the nodes of Ranvier, fr...

Multifocal motor neuropathy is a rare, acquired, immune-mediated disorder of the peripheral nervous system that selectively targets motor nerve fibers while sparing sensory nerves

Primarily affecting young to middle-aged adults—predominantly men—it presents with slowly progressive, asymmetrical muscle weakness, fasciculations, and cramping that most frequently begin in the distal upper extremities Pathophysiologically, the condition involves immune-mediated disruption of the nodes of Ranvier, frequently associated with elevated anti-GM1 IgM autoantibodies and complement activation

Its electrodiagnostic hallmark is multifocal motor conduction block occurring at sites outside usual entrapment zones, differentiating it clinically from lower motor neuron diseases