Multiple myeloma

Multiple myeloma is a hematologic malignancy characterized by the clonal proliferation of abnormal plasma cells primarily within the bone marrow

Multiple myeloma is a hematologic malignancy characterized by the clonal proliferation of abnormal plasma cells primarily within the bone marrow Pathophysiologically, the malignant expansion disrupts normal hematopoiesis and stimulates osteoclastic bone resorption while suppressing osteoblastic activity, accompanied by the overproduction of monoclonal immunoglobulins or free light chains

It predominantly affects older adults and involves the hematopoietic and skeletal systems Clinically, this leads to classic manifestations of end-organ damage, including osteolytic bone lesions, pathologic fractures, hypercalcemia, renal impairment, cytopenias such as anemia, and heightened susceptibility to infection

It predominantly affects older adults and involves the hematopoietic and skeletal systems Pathophysiologically, the malignant expansion disrupts normal hematopoiesis and stimulates osteoclastic bone resorption while suppressing osteoblastic activity, accompanied by the overproduction of monoclonal immunoglobulins or free light chains Clinically, this leads to classic manifestations of end-organ damage, including osteolytic bone lesions, pathologic fractures, hypercalcemia, renal impairment, cyto...

Pathophysiologically, the malignant expansion disrupts normal hematopoiesis and stimulates osteoclastic bone resorption while suppressing osteoblastic activity, accompanied by the overproduction of monoclonal immunoglobulins or free light chains

Clinically, this leads to classic manifestations of end-organ damage, including osteolytic bone lesions, pathologic fractures, hypercalcemia, renal impairment, cytopenias such as anemia, and heightened susceptibility to infection