Nonsquamous non-small cell lung cancer

Nonsquamous non-small cell lung cancer is a broad clinicopathologic grouping of epithelial lung malignancies that excludes squamous cell carcinoma, primarily comprising adenocarcinoma, large cell carcinoma, and other rare non-small cell subtypes Arising within the respiratory system—predominantly from the peripheral lung parenchyma and alveolar epithelium—it is the most prevalent form of non-small cell lung cancer Pathophysiologically, it is characterized by uncontrolled cellular proliferation a...

Nonsquamous non-small cell lung cancer is a broad clinicopathologic grouping of epithelial lung malignancies that excludes squamous cell carcinoma, primarily comprising adenocarcinoma, large cell carcinoma, and other rare non-small cell subtypes

Nonsquamous non-small cell lung cancer is a broad clinicopathologic grouping of epithelial lung malignancies that excludes squamous cell carcinoma, primarily comprising adenocarcinoma, large cell carcinoma, and other rare non-small cell subtypes Arising within the respiratory system—predominantly from the peripheral lung parenchyma and alveolar epithelium—it is the most prevalent form of non-small cell lung cancer

Pathophysiologically, it is characterized by uncontrolled cellular proliferation and invasiveness driven by genomic alterations, demonstrating a significantly higher frequency of actionable oncogenic driver alterations—such as mutations in EGFR or KRAS and fusions in ALK, ROS1, or RET—than squamous histology

Patients commonly present with pulmonary symptoms such as persistent cough, dyspnea, and hemoptysis, or with manifestations of locoregional invasion and distant metastasis