Osteoarthritis of the knee

Osteoarthritis of the knee is a chronic, degenerative musculoskeletal disorder characterized by the progressive deterioration and loss of articular cartilage within the knee joint

Osteoarthritis of the knee is a chronic, degenerative musculoskeletal disorder characterized by the progressive deterioration and loss of articular cartilage within the knee joint The condition predominantly affects middle-aged and older adults, with heightened risk associated with female sex, obesity, and prior joint trauma or mechanical malalignment Clinically, it manifests as activity-related or weight-bearing joint pain, morning or inactivity stiffness, joint crepitus, reduced range of motio...

Pathophysiologically, it involves whole-joint remodeling, including subchondral bone sclerosis, osteophyte formation, ligamentous laxity, and low-grade synovial inflammation

Pathophysiologically, it involves whole-joint remodeling, including subchondral bone sclerosis, osteophyte formation, ligamentous laxity, and low-grade synovial inflammation The condition predominantly affects middle-aged and older adults, with heightened risk associated with female sex, obesity, and prior joint trauma or mechanical malalignment

The condition predominantly affects middle-aged and older adults, with heightened risk associated with female sex, obesity, and prior joint trauma or mechanical malalignment Clinically, it manifests as activity-related or weight-bearing joint pain, morning or inactivity stiffness, joint crepitus, reduced range of motion, and progressive functional impairment

Clinically, it manifests as activity-related or weight-bearing joint pain, morning or inactivity stiffness, joint crepitus, reduced range of motion, and progressive functional impairment