Osteomalacia

Osteomalacia is a metabolic bone disorder characterized by the softening of the skeleton due to defective or delayed mineralization of newly formed organic bone matrix (osteoid) in mature, remodeling bone Primarily affecting adolescents and adults with closed growth plates, it most commonly arises from severe, prolonged vitamin D deficiency, abnormal vitamin D metabolism, or renal phosphate wasting

Osteomalacia is a metabolic bone disorder characterized by the softening of the skeleton due to defective or delayed mineralization of newly formed organic bone matrix (osteoid) in mature, remodeling bone Primarily affecting adolescents and adults with closed growth plates, it most commonly arises from severe, prolonged vitamin D deficiency, abnormal vitamin D metabolism, or renal phosphate wasting The resulting accumulation of unmineralized osteoid impairs structural integrity, clinically prese...

Primarily affecting adolescents and adults with closed growth plates, it most commonly arises from severe, prolonged vitamin D deficiency, abnormal vitamin D metabolism, or renal phosphate wasting

The resulting accumulation of unmineralized osteoid impairs structural integrity, clinically presenting as diffuse bone pain, bone tenderness, proximal muscle weakness, a waddling gait, and an increased risk of fragility fractures and pseudofractures (Looser zones)

The resulting accumulation of unmineralized osteoid impairs structural integrity, clinically presenting as diffuse bone pain, bone tenderness, proximal muscle weakness, a waddling gait, and an increased risk of fragility fractures and pseudofractures (Looser zones)