Paget's disease of bone

Paget's disease of bone is a chronic skeletal disorder marked by focal dysregulation of the bone remodeling cycle Pathophysiologically, hyperactive osteoclasts drive excessive bone resorption followed by disorganized osteoblastic new bone formation, producing an irregular mosaic of weakened, structurally compromised, and highly vascularized bone While often asymptomatic, affected individuals may develop deep bone pain, skeletal deformities, secondary osteoarthritis, fractures, and neurological c...

Paget's disease of bone is a chronic skeletal disorder marked by focal dysregulation of the bone remodeling cycle

It predominantly affects adults over the age of 50 and involves one or more localized skeletal sites, most commonly the pelvis, spine, femur, and skull

It predominantly affects adults over the age of 50 and involves one or more localized skeletal sites, most commonly the pelvis, spine, femur, and skull While often asymptomatic, affected individuals may develop deep bone pain, skeletal deformities, secondary osteoarthritis, fractures, and neurological compressions such as hearing loss

It predominantly affects adults over the age of 50 and involves one or more localized skeletal sites, most commonly the pelvis, spine, femur, and skull

Pathophysiologically, hyperactive osteoclasts drive excessive bone resorption followed by disorganized osteoblastic new bone formation, producing an irregular mosaic of weakened, structurally compromised, and highly vascularized bone

While often asymptomatic, affected individuals may develop deep bone pain, skeletal deformities, secondary osteoarthritis, fractures, and neurological compressions such as hearing loss