Pellagra

Pellagra is a systemic nutritional disorder caused by a severe cellular deficiency of niacin (vitamin B3) or its precursor amino acid, tryptophan, which impairs cellular metabolism and high-energy phosphate production Pathophysiologically, the condition is classically characterized by a triad often referred to as the "three Ds": photosensitive, symmetrical, hyperkeratotic dermatitis, persistent diarrhea, and neurocognitive impairment or encephalopathy, which can ultimately be fatal if left untre...

Pellagra is a systemic nutritional disorder caused by a severe cellular deficiency of niacin (vitamin B3) or its precursor amino acid, tryptophan, which impairs cellular metabolism and high-energy phosphate production Primarily affecting the cutaneous, gastrointestinal, and central nervous systems, it is observed in populations with inadequate dietary intake, chronic alcoholism, malabsorption disorders, or metabolic disruptions such as carcinoid syndrome or specific drug interactions Pathophysio...

Pellagra is a systemic nutritional disorder caused by a severe cellular deficiency of niacin (vitamin B3) or its precursor amino acid, tryptophan, which impairs cellular metabolism and high-energy phosphate production

Primarily affecting the cutaneous, gastrointestinal, and central nervous systems, it is observed in populations with inadequate dietary intake, chronic alcoholism, malabsorption disorders, or metabolic disruptions such as carcinoid syndrome or specific drug interactions

Primarily affecting the cutaneous, gastrointestinal, and central nervous systems, it is observed in populations with inadequate dietary intake, chronic alcoholism, malabsorption disorders, or metabolic disruptions such as carcinoid syndrome or specific drug interactions

Pathophysiologically, the condition is classically characterized by a triad often referred to as the "three Ds": photosensitive, symmetrical, hyperkeratotic dermatitis, persistent diarrhea, and neurocognitive impairment or encephalopathy, which can ultimately be fatal if left untreated