Postherpetic neuralgia

Postherpetic neuralgia is a chronic neuropathic pain condition that represents the most common complication of herpes zoster (shingles), which arises from the reactivation of latent varicella-zoster virus within the sensory nervous system

Postherpetic neuralgia is a chronic neuropathic pain condition that represents the most common complication of herpes zoster (shingles), which arises from the reactivation of latent varicella-zoster virus within the sensory nervous system

It disproportionately affects older adults and immunocompromised individuals

It disproportionately affects older adults and immunocompromised individuals Clinically, it is defined by persistent burning, lancinating, or aching pain—frequently accompanied by allodynia, hyperalgesia, and paresthesias—within the affected dermatome that continues for at least 90 days after the acute cutaneous rash has healed

Clinically, it is defined by persistent burning, lancinating, or aching pain—frequently accompanied by allodynia, hyperalgesia, and paresthesias—within the affected dermatome that continues for at least 90 days after the acute cutaneous rash has healed The underlying pathophysiology involves inflammatory damage and neurodegeneration of dorsal root ganglia and peripheral nerve fibers, resulting in peripheral sensitization and maladaptive central pain processing

Clinically, it is defined by persistent burning, lancinating, or aching pain—frequently accompanied by allodynia, hyperalgesia, and paresthesias—within the affected dermatome that continues for at least 90 days after the acute cutaneous rash has healed The underlying pathophysiology involves inflammatory damage and neurodegeneration of dorsal root ganglia and peripheral nerve fibers, resulting in peripheral sensitization and maladaptive central pain processing