Prevention of angioedema attacks in patient with hereditary angioedema

This indication refers to long-term routine prophylaxis in individuals diagnosed with hereditary angioedema, a rare genetic disorder typically inherited in an autosomal dominant pattern

This indication refers to long-term routine prophylaxis in individuals diagnosed with hereditary angioedema, a rare genetic disorder typically inherited in an autosomal dominant pattern Prophylactic management specifically targets the prevention of these debilitating attacks, particularly severe abdominal pain crises and potentially fatal laryngeal asphyxiation

The condition is characterized by deficient or dysfunctional C1 esterase inhibitor protein—or, less commonly, other contact-system mutations—which leads to uncontrolled plasma kallikrein activation and excessive bradykinin release Clinically, affected patients experience unpredictable, recurring episodes of nonpruritic, nonpitting subcutaneous and submucosal edema that commonly involve the limbs, face, genitalia, gastrointestinal tract, and upper respiratory tract Prophylactic management specifi...

The condition is characterized by deficient or dysfunctional C1 esterase inhibitor protein—or, less commonly, other contact-system mutations—which leads to uncontrolled plasma kallikrein activation and excessive bradykinin release