Prevention of hemorrhagic disease of newborn due to vitamin K deficiency

Prevention of hemorrhagic disease of the newborn due to vitamin K deficiency—clinically referred to as vitamin K deficiency bleeding (VKDB)—targets an acquired neonatal coagulopathy affecting the hematologic system Without preventive intervention, affected infants face severe hemorrhagic risks ranging from cutaneous and gastrointestinal bleeding to devastating intracranial hemorrhage, presenting during the early, classic, or late neonatal and infantile periods

Prevention of hemorrhagic disease of the newborn due to vitamin K deficiency—clinically referred to as vitamin K deficiency bleeding (VKDB)—targets an acquired neonatal coagulopathy affecting the hematologic system Neonates possess an intrinsic predisposition to this state because of minimal placental transfer of vitamin K, low hepatic reserves, inadequate breast milk concentrations, and an immature gut microbiome that cannot yet synthesize the vitamin Pathophysiologically, insufficient vitamin ...

Neonates possess an intrinsic predisposition to this state because of minimal placental transfer of vitamin K, low hepatic reserves, inadequate breast milk concentrations, and an immature gut microbiome that cannot yet synthesize the vitamin

Neonates possess an intrinsic predisposition to this state because of minimal placental transfer of vitamin K, low hepatic reserves, inadequate breast milk concentrations, and an immature gut microbiome that cannot yet synthesize the vitamin

Pathophysiologically, insufficient vitamin K impairs the essential post-translational gamma-carboxylation of clotting factors II, VII, IX, and X, leading to defective hemostasis