Prevention of luteinizing hormone surge when undergoing controlled ovarian hyperstimulation

Prevention of luteinizing hormone surge when undergoing controlled ovarian hyperstimulation is an endocrine management objective in women receiving exogenous gonadotropins during assisted reproductive technology procedures

Prevention of luteinizing hormone surge when undergoing controlled ovarian hyperstimulation is an endocrine management objective in women receiving exogenous gonadotropins during assisted reproductive technology procedures

In this clinical state, developing ovarian follicles secrete rising levels of estradiol, which can exert positive feedback on the hypothalamic-pituitary-ovarian axis and provoke a premature spike in endogenous luteinizing hormone If uncontrolled, this premature surge triggers premature follicular luteinization and spontaneous follicular rupture, resulting in oocyte release prior to scheduled retrieval, compromised oocyte quality, and cycle cancellation

In this clinical state, developing ovarian follicles secrete rising levels of estradiol, which can exert positive feedback on the hypothalamic-pituitary-ovarian axis and provoke a premature spike in endogenous luteinizing hormone If uncontrolled, this premature surge triggers premature follicular luteinization and spontaneous follicular rupture, resulting in oocyte release prior to scheduled retrieval, compromised oocyte quality, and cycle cancellation

If uncontrolled, this premature surge triggers premature follicular luteinization and spontaneous follicular rupture, resulting in oocyte release prior to scheduled retrieval, compromised oocyte quality, and cycle cancellation Suppressive therapy maintains follicular development under exogenous control, permitting precisely timed maturation and successful transvaginal egg retrieval

Suppressive therapy maintains follicular development under exogenous control, permitting precisely timed maturation and successful transvaginal egg retrieval