Prevention of Mycobacterium avium complex disease

The prevention of *Mycobacterium avium* complex disease is a prophylactic clinical strategy targeted primarily at severely immunocompromised individuals, most notably patients with advanced human immunodeficiency virus infection presenting with CD4 T-lymphocyte counts below 50 cells/µL In profound immunosuppression, impaired cell-mediated immunity permits hematogenous dissemination of the bacilli across multiple organ systems, resulting in severe systemic manifestations such as debilitating feve...

The prevention of *Mycobacterium avium* complex disease is a prophylactic clinical strategy targeted primarily at severely immunocompromised individuals, most notably patients with advanced human immunodeficiency virus infection presenting with CD4 T-lymphocyte counts below 50 cells/µL

*Mycobacterium avium* complex comprises environmental nontuberculous mycobacteria—principally *M. avium* and *M. intracellulare*—that can colonize the respiratory or gastrointestinal tracts

*Mycobacterium avium* complex comprises environmental nontuberculous mycobacteria—principally *M. avium* and *M. intracellulare*—that can colonize the respiratory or gastrointestinal tracts

In profound immunosuppression, impaired cell-mediated immunity permits hematogenous dissemination of the bacilli across multiple organ systems, resulting in severe systemic manifestations such as debilitating fevers, night sweats, profound weight loss, severe anemia, hepatosplenomegaly, and bacteremia

In profound immunosuppression, impaired cell-mediated immunity permits hematogenous dissemination of the bacilli across multiple organ systems, resulting in severe systemic manifestations such as debilitating fevers, night sweats, profound weight loss, severe anemia, hepatosplenomegaly, and bacteremia