Indication

Prevention of varicella after exposure

Prevention of varicella after exposure refers to post-exposure prophylaxis intended to avert or attenuate primary infection by the varicella-zoster virus (VZV) following close contact with an infected individual. Read more about Prevention of varicella after exposure

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About Prevention of varicella after exposure.

Prevention of varicella after exposure refers to post-exposure prophylaxis intended to avert or attenuate primary infection by the varicella-zoster virus (VZV) following close contact with an infected individual.

This intervention targets susceptible individuals lacking evidence of immunity, with particular focus on populations vulnerable to severe disease and complications, such as pregnant women, immunocompromised patients, and neonates.

VZV is a highly contagious alphaherpesvirus that typically replicates in the respiratory tract and regional lymphoid tissue before producing primary viremia, systemic dissemination, a characteristic pruritic vesicular exanthem, and risks of serious systemic complications such as viral pneumonitis, encephalitis, or secondary bacterial superinfections.

Prophylaxis administered during the initial incubation phase aims to disrupt viral dissemination and limit replication before widespread cutaneous and organ involvement can develop.

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