Primary biliary cholangitis

Primary biliary cholangitis is a chronic autoimmune cholestatic liver disorder characterized by T-lymphocyte–mediated inflammation and gradual destruction of the small intrahepatic bile ducts This progressive ductopenia impairs bile acid secretion, resulting in toxic intrahepatic cholestasis, chronic periportal inflammation, and downstream hepatic parenchymal damage The disease most commonly affects middle-aged women and is clinically characterized by elevated alkaline phosphatase, the presence ...

Primary biliary cholangitis is a chronic autoimmune cholestatic liver disorder characterized by T-lymphocyte–mediated inflammation and gradual destruction of the small intrahepatic bile ducts

This progressive ductopenia impairs bile acid secretion, resulting in toxic intrahepatic cholestasis, chronic periportal inflammation, and downstream hepatic parenchymal damage The disease most commonly affects middle-aged women and is clinically characterized by elevated alkaline phosphatase, the presence of serum antimitochondrial antibodies, and presenting symptoms such as fatigue and pruritus

The disease most commonly affects middle-aged women and is clinically characterized by elevated alkaline phosphatase, the presence of serum antimitochondrial antibodies, and presenting symptoms such as fatigue and pruritus Without intervention, sustained cholestasis and fibrogenesis can lead to advanced cirrhosis, portal hypertension, and end-stage liver failure

The disease most commonly affects middle-aged women and is clinically characterized by elevated alkaline phosphatase, the presence of serum antimitochondrial antibodies, and presenting symptoms such as fatigue and pruritus