Primary genital syphilis

Primary genital syphilis is the initial, localized stage of an infection caused by the spirochete bacterium *Treponema pallidum*, transmitted predominantly through sexual contact If untreated, the chancre spontaneously resolves over several weeks as the spirochetes disseminate systemically into subsequent stages of infection

Primary genital syphilis is the initial, localized stage of an infection caused by the spirochete bacterium *Treponema pallidum*, transmitted predominantly through sexual contact It affects the genitourinary tract and regional lymphatic system in sexually active adolescents and adults

It affects the genitourinary tract and regional lymphatic system in sexually active adolescents and adults

The hallmark presentation is a solitary, indurated, typically painless ulcerative lesion—known as a chancre—at the genital site of inoculation, often accompanied by non-tender regional lymphadenopathy If untreated, the chancre spontaneously resolves over several weeks as the spirochetes disseminate systemically into subsequent stages of infection

The hallmark presentation is a solitary, indurated, typically painless ulcerative lesion—known as a chancre—at the genital site of inoculation, often accompanied by non-tender regional lymphadenopathy

The hallmark presentation is a solitary, indurated, typically painless ulcerative lesion—known as a chancre—at the genital site of inoculation, often accompanied by non-tender regional lymphadenopathy

If untreated, the chancre spontaneously resolves over several weeks as the spirochetes disseminate systemically into subsequent stages of infection