Q fever endocarditis

Q fever endocarditis is a severe, chronic manifestation of infection caused by the obligate intracellular bacterium *Coxiella burnetii*, predominantly targeting the cardiovascular system

Q fever endocarditis is a severe, chronic manifestation of infection caused by the obligate intracellular bacterium *Coxiella burnetii*, predominantly targeting the cardiovascular system It develops primarily in patients with pre-existing valvular defects, prosthetic heart valves, vascular abnormalities, or underlying immunocompromise

It develops primarily in patients with pre-existing valvular defects, prosthetic heart valves, vascular abnormalities, or underlying immunocompromise

It develops primarily in patients with pre-existing valvular defects, prosthetic heart valves, vascular abnormalities, or underlying immunocompromise

Clinically, it frequently presents as blood-culture-negative endocarditis marked by an indolent course of non-specific systemic symptoms—such as prolonged fever, fatigue, and heart failure—with valvular vegetations that are often small or absent on conventional echocardiography

Clinically, it frequently presents as blood-culture-negative endocarditis marked by an indolent course of non-specific systemic symptoms—such as prolonged fever, fatigue, and heart failure—with valvular vegetations that are often small or absent on conventional echocardiography

Clinically, it frequently presents as blood-culture-negative endocarditis marked by an indolent course of non-specific systemic symptoms—such as prolonged fever, fatigue, and heart failure—with valvular vegetations that are often small or absent on conventional echocardiography

Pathophysiologically, the organism establishes persistent intracellular replication within host macrophages, leading to chronic valvular inflammation, progressive tissue destruction, and hallmark elevations in phase I *Coxiella burnetii* IgG antibody titers

Pathophysiologically, the organism establishes persistent intracellular replication within host macrophages, leading to chronic valvular inflammation, progressive tissue destruction, and hallmark elevations in phase I *Coxiella burnetii* IgG antibody titers