Retinoblastoma

Retinoblastoma is a rare, malignant intraocular tumor that originates in the neurosensory layers of the developing retina

Retinoblastoma is a rare, malignant intraocular tumor that originates in the neurosensory layers of the developing retina

Primarily affecting infants and young children under five years of age, it arises from inactivating mutations in both alleles of the *RB1* tumor suppressor gene, occurring either as a germline, heritable form that frequently presents bilaterally or as a somatic, non-heritable form that typically presents unilaterally Hallmark clinical manifestations include leukocoria, characterized by an abnormal white pupillary reflex, and strabismus, with advanced or untreated cases potentially progressing to...

Primarily affecting infants and young children under five years of age, it arises from inactivating mutations in both alleles of the *RB1* tumor suppressor gene, occurring either as a germline, heritable form that frequently presents bilaterally or as a somatic, non-heritable form that typically presents unilaterally

Hallmark clinical manifestations include leukocoria, characterized by an abnormal white pupillary reflex, and strabismus, with advanced or untreated cases potentially progressing to painful secondary glaucoma, orbital invasion, and intracranial or distant metastasis