Reversal of benzodiazepine-maintained anesthesia

Reversal of benzodiazepine-maintained anesthesia refers to the pharmacological termination of central nervous system depression following surgical or procedural general anesthesia where continuous or repeated doses of benzodiazepines were used to sustain unconsciousness This iatrogenic clinical state predominantly affects the central nervous and respiratory systems in postoperative adult and pediatric surgical patients It is pathophysiologically characterized by sustained, potentiated GABAergic ...

Reversal of benzodiazepine-maintained anesthesia refers to the pharmacological termination of central nervous system depression following surgical or procedural general anesthesia where continuous or repeated doses of benzodiazepines were used to sustain unconsciousness

This iatrogenic clinical state predominantly affects the central nervous and respiratory systems in postoperative adult and pediatric surgical patients

It is pathophysiologically characterized by sustained, potentiated GABAergic neurotransmission at gamma-aminobutyric acid type A receptor complexes, manifesting clinically as prolonged postoperative sedation, hypoventilation, delayed emergence, psychomotor impairment, and attenuated airway protective reflexes