Rhabdomyosarcoma

Rhabdomyosarcoma is an aggressive malignant soft tissue sarcoma arising from primitive mesenchymal cells committed to skeletal muscle differentiation It represents the most common soft tissue sarcoma of childhood and adolescence, though it can occasionally develop in adults Pathophysiologically, the disease is characterized by immature myogenic precursors called rhabdomyoblasts and is classified into distinct histologic and molecular subtypes, predominantly embryonal and alveolar forms, the latt...

Rhabdomyosarcoma is an aggressive malignant soft tissue sarcoma arising from primitive mesenchymal cells committed to skeletal muscle differentiation It represents the most common soft tissue sarcoma of childhood and adolescence, though it can occasionally develop in adults

Tumors most frequently arise in the head and neck, genitourinary tract, extremities, and trunk

Pathophysiologically, the disease is characterized by immature myogenic precursors called rhabdomyoblasts and is classified into distinct histologic and molecular subtypes, predominantly embryonal and alveolar forms, the latter often driven by characteristic PAX3- or PAX7-FOXO1 gene fusions

Clinically, it typically presents as an enlarging, painless mass or produces site-dependent signs of local tissue invasion and organ dysfunction