Rickettsial infection

A rickettsial infection is a vector-borne zoonotic disease caused by obligate intracellular bacteria of the genus *Rickettsia*, predominantly transmitted to humans through arthropod vectors such as ticks, fleas, lice, or mites

The pathogen targets vascular endothelial cells throughout the microvasculature, leading to systemic endangiitis and increased microvascular permeability Without prompt recognition, the resulting microvascular damage can escalate to severe multisystem complications, including non-cardiogenic pulmonary edema, encephalitis, hypovolemia, and vascular collapse

Clinically, it typically manifests as an acute febrile illness characterized by high fever, severe headache, malaise, and myalgias, often accompanied by a maculopapular or petechial rash and sometimes an inoculation eschar at the vector bite site

Clinically, it typically manifests as an acute febrile illness characterized by high fever, severe headache, malaise, and myalgias, often accompanied by a maculopapular or petechial rash and sometimes an inoculation eschar at the vector bite site

Clinically, it typically manifests as an acute febrile illness characterized by high fever, severe headache, malaise, and myalgias, often accompanied by a maculopapular or petechial rash and sometimes an inoculation eschar at the vector bite site