Scrub typhus

Scrub typhus is an acute zoonotic febrile illness caused by the obligate intracellular bacterium *Orientia tsutsugamushi* and transmitted to humans through the bite of infected larval trombiculid mites, commonly known as chiggers It primarily affects individuals living in or traveling through endemic rural and brush-vegetated regions across the Asia-Pacific region and beyond Defining clinical features include high fever, severe headache, myalgia, lymphadenopathy, a maculopapular rash, and freque...

Scrub typhus is an acute zoonotic febrile illness caused by the obligate intracellular bacterium *Orientia tsutsugamushi* and transmitted to humans through the bite of infected larval trombiculid mites, commonly known as chiggers It primarily affects individuals living in or traveling through endemic rural and brush-vegetated regions across the Asia-Pacific region and beyond Defining clinical features include high fever, severe headache, myalgia, lymphadenopathy, a maculopapular rash, and freque...

Scrub typhus is an acute zoonotic febrile illness caused by the obligate intracellular bacterium *Orientia tsutsugamushi* and transmitted to humans through the bite of infected larval trombiculid mites, commonly known as chiggers Pathophysiologically, the organism infects vascular endothelial cells and reticuloendothelial tissue, leading to widespread microvascular inflammation and increased vascular permeability Defining clinical features include high fever, severe headache, myalgia, lymphadeno...

It primarily affects individuals living in or traveling through endemic rural and brush-vegetated regions across the Asia-Pacific region and beyond

Defining clinical features include high fever, severe headache, myalgia, lymphadenopathy, a maculopapular rash, and frequently a pathognomonic necrotic eschar at the inoculation site; severe untreated infections can progress to pneumonitis, meningoencephalitis, acute kidney injury, and multiorgan failure