Serum sickness

Serum sickness is a systemic type III immune-complex-mediated hypersensitivity reaction that arises following exposure to foreign antigens, historically heterologous animal antisera and currently therapeutic biologic agents or foreign proteins Clinically, it characteristically manifests one to two weeks following exposure with a classic triad of fever, an urticarial or morbilliform cutaneous rash, and polyarthralgia or arthritis, frequently accompanied by lymphadenopathy

Serum sickness is a systemic type III immune-complex-mediated hypersensitivity reaction that arises following exposure to foreign antigens, historically heterologous animal antisera and currently therapeutic biologic agents or foreign proteins

It develops when circulating antibodies bind to the offending antigen, forming immune complexes that deposit within small blood vessel walls across various organs, predominantly affecting the skin, joints, and kidneys This deposition triggers classical complement pathway activation, resulting in hypocomplementemia and localized vascular inflammation

It develops when circulating antibodies bind to the offending antigen, forming immune complexes that deposit within small blood vessel walls across various organs, predominantly affecting the skin, joints, and kidneys This deposition triggers classical complement pathway activation, resulting in hypocomplementemia and localized vascular inflammation

Clinically, it characteristically manifests one to two weeks following exposure with a classic triad of fever, an urticarial or morbilliform cutaneous rash, and polyarthralgia or arthritis, frequently accompanied by lymphadenopathy