Severe persistent asthma

Severe persistent asthma is the most advanced baseline severity classification of asthma, a chronic inflammatory disorder of the lower respiratory tract characterized by bronchial hyperresponsiveness and variable airflow obstruction

Severe persistent asthma is the most advanced baseline severity classification of asthma, a chronic inflammatory disorder of the lower respiratory tract characterized by bronchial hyperresponsiveness and variable airflow obstruction Across pediatric and adult populations, it is clinically defined by continuous daily symptoms, frequent nighttime awakenings, extreme limitation of physical activity, and recurring exacerbations Pathophysiologically, persistent mucosal inflammation, goblet cell hyper...

Across pediatric and adult populations, it is clinically defined by continuous daily symptoms, frequent nighttime awakenings, extreme limitation of physical activity, and recurring exacerbations Pathophysiologically, persistent mucosal inflammation, goblet cell hyperplasia, and airway smooth muscle remodeling contribute to marked baseline lung impairment, typically evidenced by a forced expiratory volume in one second (FEV1) of less than 60% of predicted normal values