Sjogren's syndrome

Sjögren's syndrome is a chronic, systemic autoimmune disease primarily characterized by immune-mediated inflammation and progressive destruction of exocrine tissue, most notably the salivary and lacrimal glands Pathophysiologically, lymphocytic infiltration of the glandular epithelium, aberrant B-cell activation, and autoantibody production—such as anti-Ro/SSA and anti-La/SSB—drive glandular dysfunction and can extend to cause extraglandular involvement across pulmonary, renal, neurological, and...

Sjögren's syndrome is a chronic, systemic autoimmune disease primarily characterized by immune-mediated inflammation and progressive destruction of exocrine tissue, most notably the salivary and lacrimal glands It predominantly affects adult women and presents with hallmark sicca symptoms, including dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia), often accompanied by profound fatigue and arthralgias

It predominantly affects adult women and presents with hallmark sicca symptoms, including dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia), often accompanied by profound fatigue and arthralgias

Pathophysiologically, lymphocytic infiltration of the glandular epithelium, aberrant B-cell activation, and autoantibody production—such as anti-Ro/SSA and anti-La/SSB—drive glandular dysfunction and can extend to cause extraglandular involvement across pulmonary, renal, neurological, and vascular systems

Pathophysiologically, lymphocytic infiltration of the glandular epithelium, aberrant B-cell activation, and autoantibody production—such as anti-Ro/SSA and anti-La/SSB—drive glandular dysfunction and can extend to cause extraglandular involvement across pulmonary, renal, neurological, and vascular systems