Skin and skin structure infection

A skin and skin structure infection (often categorized as uncomplicated or complicated, and closely related to acute bacterial skin and skin structure infections) is a microbial invasion affecting the integumentary system, including the epidermis, dermis, and deeper subcutaneous tissues Pathophysiologically, it typically arises when a disruption in the epithelial barrier permits colonization and proliferation of pathogens—predominantly *Staphylococcus aureus* and *Streptococcus pyogenes*—which t...

A skin and skin structure infection (often categorized as uncomplicated or complicated, and closely related to acute bacterial skin and skin structure infections) is a microbial invasion affecting the integumentary system, including the epidermis, dermis, and deeper subcutaneous tissues

Pathophysiologically, it typically arises when a disruption in the epithelial barrier permits colonization and proliferation of pathogens—predominantly *Staphylococcus aureus* and *Streptococcus pyogenes*—which trigger local and sometimes systemic inflammatory cascades

Clinically, these infections present along a wide spectrum ranging from superficial pyodermas, folliculitis, and simple abscesses to extensive cellulitis, erysipelas, infected surgical or traumatic wounds, and deep fascial necrosis

Clinically, these infections present along a wide spectrum ranging from superficial pyodermas, folliculitis, and simple abscesses to extensive cellulitis, erysipelas, infected surgical or traumatic wounds, and deep fascial necrosis

Hallmarks include localized erythema, warmth, edema, and tenderness, which may be accompanied by purulent drainage, tissue induration, or systemic signs of toxicity depending on the depth and severity of involvement

Hallmarks include localized erythema, warmth, edema, and tenderness, which may be accompanied by purulent drainage, tissue induration, or systemic signs of toxicity depending on the depth and severity of involvement