Skin irritation

Skin irritation is a localized, non-immunologic inflammatory reaction of the integumentary system provoked by direct physical, chemical, or environmental disruption of the stratum corneum

Skin irritation is a localized, non-immunologic inflammatory reaction of the integumentary system provoked by direct physical, chemical, or environmental disruption of the stratum corneum Pathophysiologically, disruption of the epidermal barrier triggers innate immune activation and the local release of pro-inflammatory cytokines, causing microvascular dilation and transepidermal water loss

This condition can affect individuals of any age group, particularly in exposed areas such as the hands, face, or intertriginous skin folds Pathophysiologically, disruption of the epidermal barrier triggers innate immune activation and the local release of pro-inflammatory cytokines, causing microvascular dilation and transepidermal water loss

This condition can affect individuals of any age group, particularly in exposed areas such as the hands, face, or intertriginous skin folds

It is clinically characterized by localized erythema, mild edema, scaling, dryness, and subjective discomfort such as pruritus, stinging, or burning sensations

It is clinically characterized by localized erythema, mild edema, scaling, dryness, and subjective discomfort such as pruritus, stinging, or burning sensations