Indication

Sleep-onset insomnia

Sleep-onset insomnia, also known as initial insomnia, is a sleep disorder characterized by difficulty initiating sleep at bedtime despite adequate opportunity and circumstances for rest. Read more about Sleep-onset insomnia

72 drugs 54 manufacturers

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Drugs that treat it

Common Sleep-onset insomnia therapies.

Showing 37–45 of 72 drugs

RAMELTEON

HYPNOTICS·SLEEP-ONSET INSOMNIA
TRUPHARMA, LLC.

ZALEPLON

HYPNOTICS·SLEEP-ONSET INSOMNIA
A-S MEDICATION

RAMELTEON

HYPNOTICS·SLEEP-ONSET INSOMNIA
GSMS, INC.

RAMELTEON

HYPNOTICS·SLEEP-ONSET INSOMNIA
DIRECT RX

ZALEPLON

HYPNOTICS·SLEEP-ONSET INSOMNIA
DIRECT RX
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About Sleep-onset insomnia.

Sleep-onset insomnia, also known as initial insomnia, is a sleep disorder characterized by difficulty initiating sleep at bedtime despite adequate opportunity and circumstances for rest.

It involves central nervous system dysregulation and can affect individuals of any age group, though it is particularly prevalent in adolescents and young adults.

Clinically, it is defined by prolonged sleep-onset latency—commonly exceeding 30 minutes—which frequently leads to daytime fatigue, cognitive impairment, mood disturbances, and reduced functional capacity.

Pathophysiologically, the condition is driven by cognitive, somatic, and neuroendocrine hyperarousal, characterized by elevated sympathetic nervous system tone, increased evening cortisol secretion, and heightened metabolic activity that impede the transition into non-rapid eye movement sleep.

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