Status asthmaticus

Status asthmaticus is an acute, life-threatening exacerbation of asthma characterized by severe bronchospasm and progressive airflow obstruction that is refractory to initial standard bronchodilator and corticosteroid therapy

It primarily affects pediatric and adult patients with preexisting bronchial asthma, involving widespread lower airway inflammation, excessive mucus plugging, and airway hyperresponsiveness Pathophysiologically, severe ventilation-perfusion mismatch leads to marked work of breathing, dynamic pulmonary hyperinflation, hypoxemia, and carbon dioxide retention, which can rapidly progress to respiratory muscle fatigue, acute hypercapnic respiratory failure, and cardiac arrest

It primarily affects pediatric and adult patients with preexisting bronchial asthma, involving widespread lower airway inflammation, excessive mucus plugging, and airway hyperresponsiveness

Pathophysiologically, severe ventilation-perfusion mismatch leads to marked work of breathing, dynamic pulmonary hyperinflation, hypoxemia, and carbon dioxide retention, which can rapidly progress to respiratory muscle fatigue, acute hypercapnic respiratory failure, and cardiac arrest

Pathophysiologically, severe ventilation-perfusion mismatch leads to marked work of breathing, dynamic pulmonary hyperinflation, hypoxemia, and carbon dioxide retention, which can rapidly progress to respiratory muscle fatigue, acute hypercapnic respiratory failure, and cardiac arrest