Stevens-Johnson syndrome

Stevens-Johnson syndrome is an acute, life-threatening type IV mucocutaneous hypersensitivity reaction characterized by extensive keratinocyte apoptosis, leading to epidermal detachment and mucosal sloughing Representing the less extensive presentation along a shared disease spectrum with toxic epidermal necrolysis, it specifically features epidermal necrosis and detachment involving less than 10% of the total body surface area The condition predominantly affects adults—particularly individuals ...

Stevens-Johnson syndrome is an acute, life-threatening type IV mucocutaneous hypersensitivity reaction characterized by extensive keratinocyte apoptosis, leading to epidermal detachment and mucosal sloughing The condition predominantly affects adults—particularly individuals with specific human leukocyte antigen variants or underlying immunodeficiency—and typically presents with a systemic flu-like prodrome followed by painful coalescing macules, bullae, and painful erosions involving at least t...

Stevens-Johnson syndrome is an acute, life-threatening type IV mucocutaneous hypersensitivity reaction characterized by extensive keratinocyte apoptosis, leading to epidermal detachment and mucosal sloughing Representing the less extensive presentation along a shared disease spectrum with toxic epidermal necrolysis, it specifically features epidermal necrosis and detachment involving less than 10% of the total body surface area The condition predominantly affects adults—particularly individuals ...

The condition predominantly affects adults—particularly individuals with specific human leukocyte antigen variants or underlying immunodeficiency—and typically presents with a systemic flu-like prodrome followed by painful coalescing macules, bullae, and painful erosions involving at least two mucosal sites, most commonly the oral cavity, ocular conjunctiva, and genitalia