Synergy for Citrobacter meningitis

Synergy for *Citrobacter* meningitis refers to the pharmacodynamic objective of using combination antimicrobial therapy to produce an enhanced, supra-additive bactericidal effect against central nervous system infections caused by *Citrobacter* species (predominantly *Citrobacter koseri* or *Citrobacter freundii*) Because *Citrobacter* isolates frequently harbor chromosomal AmpC beta-lactamases or plasmid-mediated extended-spectrum beta-lactamases that confer multidrug resistance, synergistic re...

Synergy for *Citrobacter* meningitis refers to the pharmacodynamic objective of using combination antimicrobial therapy to produce an enhanced, supra-additive bactericidal effect against central nervous system infections caused by *Citrobacter* species (predominantly *Citrobacter koseri* or *Citrobacter freundii*)

Synergy for *Citrobacter* meningitis refers to the pharmacodynamic objective of using combination antimicrobial therapy to produce an enhanced, supra-additive bactericidal effect against central nervous system infections caused by *Citrobacter* species (predominantly *Citrobacter koseri* or *Citrobacter freundii*) Because *Citrobacter* isolates frequently harbor chromosomal AmpC beta-lactamases or plasmid-mediated extended-spectrum beta-lactamases that confer multidrug resistance, synergistic re...

Synergy for *Citrobacter* meningitis refers to the pharmacodynamic objective of using combination antimicrobial therapy to produce an enhanced, supra-additive bactericidal effect against central nervous system infections caused by *Citrobacter* species (predominantly *Citrobacter koseri* or *Citrobacter freundii*) This clinical state involves severe inflammation of the meninges and cerebral tissue, most characteristically occurring in neonates and young infants, though occasionally affecting imm...

This clinical state involves severe inflammation of the meninges and cerebral tissue, most characteristically occurring in neonates and young infants, though occasionally affecting immunocompromised or post-neurosurgical adults Because *Citrobacter* isolates frequently harbor chromosomal AmpC beta-lactamases or plasmid-mediated extended-spectrum beta-lactamases that confer multidrug resistance, synergistic regimens are utilized to accelerate cerebrospinal fluid sterilization and mitigate rapid p...

This clinical state involves severe inflammation of the meninges and cerebral tissue, most characteristically occurring in neonates and young infants, though occasionally affecting immunocompromised or post-neurosurgical adults

It is pathologically distinguished by invasive bacterial vasculitis, extensive tissue necrosis, and a disproportionately high incidence of ventriculitis and liquefactive brain abscess formation

It is pathologically distinguished by invasive bacterial vasculitis, extensive tissue necrosis, and a disproportionately high incidence of ventriculitis and liquefactive brain abscess formation

It is pathologically distinguished by invasive bacterial vasculitis, extensive tissue necrosis, and a disproportionately high incidence of ventriculitis and liquefactive brain abscess formation