Systemic lupus erythematosus

Systemic lupus erythematosus is a chronic, multisystem autoimmune disorder characterized by loss of immune tolerance, aberrant activation of B and T lymphocytes, and the production of pathogenic autoantibodies, most notably antinuclear antibodies It predominantly affects women of childbearing age and exhibits a relapsing and remitting course of widespread inflammation and immune-complex deposition

Systemic lupus erythematosus is a chronic, multisystem autoimmune disorder characterized by loss of immune tolerance, aberrant activation of B and T lymphocytes, and the production of pathogenic autoantibodies, most notably antinuclear antibodies It predominantly affects women of childbearing age and exhibits a relapsing and remitting course of widespread inflammation and immune-complex deposition

Clinical manifestations are highly heterogeneous and can affect virtually any organ system, commonly presenting with constitutional symptoms, inflammatory arthritis, mucocutaneous lesions such as a malar rash, serositis, hematologic cytopenias, and potentially severe renal, neuropsychiatric, or cardiovascular complications

Clinical manifestations are highly heterogeneous and can affect virtually any organ system, commonly presenting with constitutional symptoms, inflammatory arthritis, mucocutaneous lesions such as a malar rash, serositis, hematologic cytopenias, and potentially severe renal, neuropsychiatric, or cardiovascular complications