Indication

Systemic mastocytosis

Systemic mastocytosis is a rare clonal hematologic neoplasm characterized by the abnormal proliferation and accumulation of genetically altered mast cells within extracutaneous tissues, most commonly the bone marrow, liver, spleen, gastrointestinal tract, and lymph nodes. Read more about Systemic mastocytosis

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CROMOLYN SODIUM

MAST-CELL STABILIZER-TYPE ANTI-ALLERGY SYSTEMIC AGENTS·SYSTEMIC MASTOCYTOSIS

WALLACE/MYLAN

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About Systemic mastocytosis.

It predominantly affects adults and is driven in most patients by activating somatic mutations in the *KIT* receptor tyrosine kinase gene, such as KIT D816V.

Clinical manifestations range from indolent to aggressive disease, driven both by mast cell mediator release—causing episodic flushing, pruritus, abdominal pain, hypotension, and anaphylaxis—and by tissue infiltration that can lead to cytopenias, organomegaly, and end-organ dysfunction.

cancer.gov
Systemic mastocytosis is a rare clonal hematologic neoplasm characterized by the abnormal proliferation and accumulation of genetically altered mast cells within extracutaneous tissues, most commonly the bone marrow, liver, spleen, gastrointestinal tract, and lymph nodes Clinical manifestations range from indolent to aggressive disease, driven both by mast cell mediator release—causing episodic flushing, pruritus, abdominal pain, hypotension, and anaphylaxis—and by tissue infiltration that can l...
medlineplus.gov
Systemic mastocytosis is a rare clonal hematologic neoplasm characterized by the abnormal proliferation and accumulation of genetically altered mast cells within extracutaneous tissues, most commonly the bone marrow, liver, spleen, gastrointestinal tract, and lymph nodes It predominantly affects adults and is driven in most patients by activating somatic mutations in the *KIT* receptor tyrosine kinase gene, such as KIT D816V
nih.gov
Systemic mastocytosis is a rare clonal hematologic neoplasm characterized by the abnormal proliferation and accumulation of genetically altered mast cells within extracutaneous tissues, most commonly the bone marrow, liver, spleen, gastrointestinal tract, and lymph nodes
mayoclinic.org
It predominantly affects adults and is driven in most patients by activating somatic mutations in the *KIT* receptor tyrosine kinase gene, such as KIT D816V Clinical manifestations range from indolent to aggressive disease, driven both by mast cell mediator release—causing episodic flushing, pruritus, abdominal pain, hypotension, and anaphylaxis—and by tissue infiltration that can lead to cytopenias, organomegaly, and end-organ dysfunction
medlineplus.gov
Clinical manifestations range from indolent to aggressive disease, driven both by mast cell mediator release—causing episodic flushing, pruritus, abdominal pain, hypotension, and anaphylaxis—and by tissue infiltration that can lead to cytopenias, organomegaly, and end-organ dysfunction
bioontology.org
Clinical manifestations range from indolent to aggressive disease, driven both by mast cell mediator release—causing episodic flushing, pruritus, abdominal pain, hypotension, and anaphylaxis—and by tissue infiltration that can lead to cytopenias, organomegaly, and end-organ dysfunction

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