Ulcerative proctitis

Ulcerative proctitis is a localized phenotypic subtype of ulcerative colitis, a chronic inflammatory bowel disease affecting the lower gastrointestinal tract

Ulcerative proctitis is a localized phenotypic subtype of ulcerative colitis, a chronic inflammatory bowel disease affecting the lower gastrointestinal tract

The condition is confined strictly to the rectal mucosa, originating at the dentate line and extending proximally without exceeding approximately fifteen centimeters from the anal verge

The condition is confined strictly to the rectal mucosa, originating at the dentate line and extending proximally without exceeding approximately fifteen centimeters from the anal verge Pathophysiologically driven by immune-mediated epithelial barrier dysfunction and mucosal inflammation, it is characterized endoscopically by confluent mucosal erythema, friability, and ulceration Clinically, affected patients most commonly present with recurrent hematochezia, fecal urgency, tenesmus, and the pas...

Pathophysiologically driven by immune-mediated epithelial barrier dysfunction and mucosal inflammation, it is characterized endoscopically by confluent mucosal erythema, friability, and ulceration

Clinically, affected patients most commonly present with recurrent hematochezia, fecal urgency, tenesmus, and the passage of rectal mucus, while systemic manifestations remain infrequent