Indication

Vasomotor symptoms associated with menopause

Vasomotor symptoms associated with menopause refer to episodic neurovascular disturbances—predominantly hot flashes and night sweats—experienced by individuals during the perimenopausal and postmenopausal transitions. Read more about Vasomotor symptoms associated with menopause

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About Vasomotor symptoms associated with menopause.

Vasomotor symptoms associated with menopause refer to episodic neurovascular disturbances—predominantly hot flashes and night sweats—experienced by individuals during the perimenopausal and postmenopausal transitions.

Arising from age-related ovarian follicular depletion and subsequent estrogen withdrawal, these symptoms stem from thermoregulatory dysfunction within the hypothalamus, particularly involving hypertrophied kisspeptin, neurokinin B, and dynorphin neurons.

This central dysregulation narrows the core body temperature homeostatic threshold, triggering inappropriate heat-dissipation responses characterized by sudden cutaneous vasodilation, intense flushing of the upper body and face, profuse diaphoresis, and transient palpitations or chills.

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